Endocrine Abstracts

The recent discovery of the importance of kisspeptin-GPR54 signaling to the onset of puberty in humans has generated intense interest in understanding the mechanisms and pathways of kisspeptin-GPR54 signaling at the gonadotropin-releasing hormone (GnRH) neurons. Using transgenic mouse models, electrophysiology and immunocytochemistry we have shown that kisspeptin strongly activates adult GnRH neurons and that these cells receive a direct input from kisspeptin neurons located i...